Some of you may know that there's lots of Programs that you can use with Twitter to do more with Twitter, than just the basic view you get on the website. (You can see a few choice Twitter Clients at
http://twitter.com/downloads and the full list of everything Twitter Apps related here :
http://twitter.pbworks.com/Apps
Personally, I would recommend
TweetDeck, as my 1st Choice. It's the original and all time favourite Twitter Desktop App, for all my friends, and many long time users of Twitter that I know. I've also found
Seesmic's Desktop useful, and helpful, especially when juggling a personal Twitter Account with a more Geneology focussed one ;) I'm also a big fan of
http://hootsuite.com - especially if you have to share a twitter account with more than one person!