Haplogroup - C1b2a

Replies to This Discussion

Permalink Reply by Ugo A. Perego on July 19, 2009 at 10:49pm

Is your husband sequence deposited in GenBank? If not, would he be interested in knowing why and how he should do it? Was the haplogroup classification something he received when he had his complete mtDNA sequence done, or did someone else help you determining it? In the Achilli et al. 2008 paper (available for free online), there are 13 samples belonging to C1b2a (3 different haplotypes), namely #106, #107, and #108 (figure 3). Does your husband match any of them?

Permalink Reply by Ruth on July 20, 2009 at 9:12am

Hi Ugo,
No, my husband's sequence is not deposit in the GenBank database. I was planning on having it done and just kept putting it off. I know of someone that can help me with it, I had mine done.
He received his classification when he did his full sequence. Other then his three matches from FTDNA, I found one that match his results with a difference of one mutation from each from a Canary person.
Mitochondrial Population Genomics Supports a Single Pre-Clovis Origin with a Coastal Route for the Peopling of the Americas
Nelson J.R. Fagundes,1,2,7 Ricardo Kanitz,1,7 Roberta Eckert,1 Ana C.S. Valls,1 Mauricio R. Bogo,1 Francisco M. Salzano,2 David Glenn Smith,3 Wilson A. Silva Jr.,4 Marco A. Zago,4
Andrea K. Ribeiro-dos-Santos,5 Sidney E.B. Santos,5 Maria Luiza Petzl-Erler,6 and Sandro L. Bonatto1,*

GenBank Accession Number
C1 haplotype C AF382009 Canary 42

Are those samples that you mentioned posted in Ian Logan mtdna site?

Permalink Reply by Ruth on July 20, 2009 at 10:00am

I think the Accession number of AF382009 was changed to AF382009.2 Maca-Meyer in the GenBank database.

Permalink Reply by Ugo A. Perego on July 20, 2009 at 1:44pm

Hi Ruth. I saw the Canary Island sample in GenBank. Interesting that it is from that part of the world. I am pretty sure that it has to do with some of those Native Americans that were taken to Europe shortly after the discovery of the American continent. There is a small amount of Native American lineages that once in a while appear in people tested in Spain and England for the same reason. The Achilli et al. samples are on Ian Logan site. The C1b tree include the Canary sample (with the private mutation 12574) as well as the samples from the Achilli paper. The reference in the Ian Logan list is Achilli et al. 2008, but the samples were deposited in GenBank by Parsons and later published as a dataset by Just et al. 2008. Ian Logan has instructions on how to deposit a sequence in GenBank at http://www.ianlogan.co.uk/Submission.htm (but I am sure you already knew it!). :) Once his sequence is deposited, please let me know and I will add his data to my Native American mtDNA trees... Thank you!

Permalink Reply by Ruth on July 20, 2009 at 1:54pm

Hi Ugo,
I will let you know when it will be posted.
Can you tell me anything about private mutation 12574?

Ruth

Permalink Reply by Ruth on July 20, 2009 at 2:33pm

Ugo
OK, private mutation T12574C is the one my husband does not have.
I didn't know that it was considered a private mutation.

Permalink Reply by Ugo A. Perego on July 20, 2009 at 8:17pm

Hi Ruth, let me know if you don't know what a private mutation is and I will be happy to explain it to you. If you would like, you can email me your husband's haplotype (ugo@smgf.org) and I will make sure that you did not miss out on anything. The subclade is pretty specific and there are just a handful of samples in the public domain that belong to C1b2a. I can compare your husband hapolotype with each one of them and let you know which one is the closest match to his mtDNA. Let me know. Thanks.

Permalink Reply by Ruth on July 20, 2009 at 8:51pm

Hi Ugo,
I just send you an email. Check your spam folder just in case.

Ruth

Permalink Reply by Ruth on October 3, 2009 at 6:54pm

My paternal grandmother is of haplogroup C and my father's mtdna results match those of my husband's.
Wish I knew who the ancestor was that connects to my family and husband's family. Oh well.

Permalink Reply by John E Montanez on May 12, 2010 at 12:19pm

"...How many of you were assigned to haplogroup C1b2a?"

That would be me! I am in this haplogroup. I live in Florida. And! It looks like your husband has another genetic cousin. :O)

Here are my results, which are the same as my mother's of course.
C1b2a
HVR1-16223T, 16298C, 16325C, 16327T, 16519C
HVR2 - 73G, 249-, 290-, 291-, 315.1C, 489C, 493G, 522-, 523-

My father's maternal mtDNA is haplogroup C1b

Here are his results.
C1b
16223T, 16248T, 16298C, 16299G, 16325C, 16327T

Permalink Reply by Ruth on May 12, 2010 at 4:19pm

Far too many were assigned C1b2a. Can't believe how many.
Who were you tested with? John, your name looks very familiar.

Ruth

Permalink Reply by John E Montanez on May 12, 2010 at 6:47pm

I was tested by FTDNA, but Doctor Ana Oquendo Pabón of the mtDNA Amerind Founder Haplogroup Project did the assignment to C1b2a. She has 21 of us listed under the C1b2a heading though only one appears to be confirmed. I have no idea what criteria she is using. FTDNA lists 42 matches but only nine as C1b2a and twenty-five as C. I have no idea what criteria Doctor Ana Oquendo Pabón is using to make the assignment.
http://www.familytreedna.com/public/AmerindFoundermtDNA/default.asp...

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