The two genealogy CDs that I use most often are the LDS Family History Suite, produced in 1996. It has the best collection of pioneer photographs and biographies, and the largest collection of materials from the Daughters of the Utah Pioneers that I have ever used. It uses the Folio VIEWS search engine, which is very powerful. I have spend hundreds of hours with this product and can find more pioneer photographs and biographies on this product than in any other place.
The other CD I use is the Ancestry Reference Library which was produced before 2000--it contains the full text of The Source, The RedBook and several other popular Ancestry books, again in the Folio VIEWS format. I love the full text indexing and the way the search engine combines terms and shows you visually and instantly how many paragraphs contain all of your search terms.